An error by Ole Miss shortstop Errol Robinson with one out in the 13th allowed LSU to score the go-ahead run.
Jeremy Massie came on in relief of Josh Laxer to strand three and get out of the inning with a one-run deficit, but the Rebels were unable to rally in the home half of the 13th.
Laxer, the third Ole Miss pitcher, took the loss. In two innings he gave up three hits and two walks – one intentional – but the only run he allowed was unearned.
Kurt McCune, LSU’s fourth pitcher, retired Auston Bousfield, Austin Anderson and pinch-hitter Brantley Bell in order to close out the game.
Wyatt Short had pitched two scoreless relief innings when he gave up a leadoff single in the 11th. After a sacrifice bunt Short was replaced by Laxer, who allowed the runner to advance to third with a wild pitch before Jake Fraley’s RBI hit gave the Tigers a 3-2 lead.
The Rebels tied the game in the bottom of the inning on a leadoff single from Will Allen, an LSU throwing error and fly balls from Sikes Orvis and JB Woodman, the later scoring pinch-runner Cameron Dishon.
Ole Miss starter Chris Ellis went eight innings, LSU starter Aaron Nola 7.2 innings.
The Rebels scored on an Orvis home run in the second, his ninth of the year, and were down 2-1 when they scratched out a run on two hits and a walk to tie the game in the bottom of the eighth.
The RBI came on a ground ball by Allen against Nola. Orvis, batting against Joe Broussard, was unable to drive in runners from second and third with two outs.
Game 2 is Friday at 6:30 p.m.