The new reported case is in Newton County. In February, health officials reported a case in Hinds County.
The state health department only reports laboratory-confirmed cases to the public. In 2013, Mississippi had 45 West Nile cases and five deaths.
State Epidemiologist Dr. Thomas Dobbs says the second case is a reminder of the importance of preventing mosquito exposures, particularly ahead of the active summer months.
In 2012, Mississippi had 247 West Nile cases and five deaths.