The project will add more than six miles of I-269 from Shinault Road in Byhalia to Mississippi Highway 302 in Marshall County.
Northern District Transportation Commissioner Mike Tagert says in a news release that all sections of the highway are now in the construction phase in Mississippi.
Tagert says I-269 will provide a means for commercial vehicles to move raw materials and manufactured goods through the region.
Construction of I-269 includes seven projects and about 25 miles of four-lane highway from Interstate 55 near Hernando through DeSoto and Marshall counties to the Tennessee state line.
Construction on the $286 million interstate project began in 2011 and is scheduled to be complete in fall 2015.