The Mississippi Department of Transportation will close the southern railroad crossing on Highway 45 Alternate in West Point on Wednesday and Thursday.
The Kansas City Southern railroad is repairing rails and repaving the crossing, and the work will shut down 45A between Churchill Road and Airport Road.
The detour will be a 31-mile route along Highways 50, 45 and 82. Detour signage will be in place to direct traffic.
The road will be closed from 8 p.m. Wednesday to 6 a.m. Thursday. Crews will then begin alternating lane closures at 6 a.m. Thursday and will continue to do so until all lanes at the crossing are paved.