GEORGE WILL: Starved by the sequester

“The capacity to blunder slightly is the real marvel of DNA. Without this special attribute, we would still be anaerobic bacteria and there would be no music.”
– Lewis Thomas

The pedigree of human beings, Thomas wrote, probably traces to a single cell fertilized by a lightning bolt as the Earth was cooling. Fortunately, genetic “mistakes” – mutations – eventually made us. But they also have made illnesses. Almost all diseases arise from some combination of environmental exposures and genetic blunders in the working of DNA. Breast cancer is a family of genetic mutations.

The great secret of doctors, wrote Thomas – who was a physician, philosopher and head of the Memorial Sloan-Kettering Cancer Center – “is that most things get better by themselves; most things, in fact, are better in the morning.” But many things require intelligent interventions – cures. So, to see the federal government at its best, and sequester-driven spending cuts at their worst, visit the 322 acres where 25,000 people work for the National Institutes of Health.

This 60th anniversary of the Clinical Center, the NIH’s beating heart, is inspiriting and depressing: Public health is being enhanced – rapidly, yet unnecessarily slowly – by NIH-supported research here, and in hundreds of institutions across the country, into new drugs, devices and treatments.
Yet, much research proposed by extraordinarily talented physicians and scientists cannot proceed because the required funding is prevented by the intentional irrationality by which the sequester is administered.

A 2 percent reduction of federal spending would be easily manageable. It has, however, been made deliberately dumb by mandatory administrative rigidities intended to maximize pain in order to weaken resistance to any spending restraint. Spending on basic medical research is being starved as the river of agriculture subsidies rolls on.

For Francis Collins, being the NIH’s director is a daily experience of exhilaration and dismay. In the last 40 years, he says, heart attacks and strokes have declined 60 percent and 70 percent, respectively. Cancer deaths are down 15 percent in 15 years.

An AIDS diagnosis is no longer a death sentence. Researchers are on the trail of a universal flu vaccine, based on new understandings of the influenza virus and the human immune system. Chemotherapy was invented here – and is being replaced by treatments developed here. Yet the pace of public health advances is, Collins says, being slowed by the sequester.

He entered federal service to oversee decoding the human genome, which he describes as “reading out the instruction book for human beings.” We are, he says, at the dawn of the era of “precision medicine,” of treatments personalized for patients’ genetic makeups.

This will be, Collins believes, “the century of biology.” Other countries have “read our playbook,” seeing how biomedical research can reduce health costs, produce jobs and enhance competitiveness. Meanwhile, America’s great research universities award advanced degrees to young scientists from abroad, and then irrational immigration policy compels them to leave and add value to other countries. And now the sequester discourages and disperses scientific talent.

In the private sector, where investors expect a quick turnaround, it is difficult to find dollars for a 10-year program. The public sector, however, with its different time horizon, can fund for the long term, thereby drawing young scientists into career trajectories and collaborations impossible elsewhere.

Collins is haunted by knowledge that the flow of scientific talent cannot be turned on and off like a faucet. Unfortunately, recent government behavior has damaged the cause of basic science. It has blurred the distinction between fundamental research and technical refinements (often of 19th-century technologies – faster trains, better batteries, longer-lived light bulbs).

It has sown confusion about the difference between supporting scientific research and practicing industrial policy with subsidies – often incompetently and sometimes corruptly dispensed – for private corporations oriented to existing markets rather than unimagined applications. And beginning with the indiscriminate and ineffective 2009 stimulus, government has incited indiscriminate hostility to public spending.

NIH scientists seek intensely practical, meaning preventive and therapeutic, things that can save society more than any sequester can. The scientists also know, however, that the enchantment of science is in the phrase “You never know.” You never know where things might lead. Sixty years ago, James Watson and Francis Crick published a paper in the journal Nature describing the double-helix structure of DNA and noting almost laconically that it “suggests a possible copying mechanism for the genetic material.” They could not have known that this would lead to Collins’ career, which has led him here to days of dismay about exhilarations postponed.

GEORGE WILL’S email address is

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    All true. What I find extraordinarily ironic, is these same collective ‘investment’ ideals Mr. Will appears to be extolling in his NIH analogy are the foundation of Democratic political policy. These are the same ideals at the base of ‘Obamacare’; you know that new health care initiative the
    Republicans want to defund piece by piece. The same on which Social Security, Medicare, and yes, the NIH all share of which have and are targeted by the Republicans in their ‘defunding’
    efforts. Indeed the NIH’s current problems didn’t begin with the sequester, no they began with a Republican policy during the Bush administration which sought to sever NIH bloodlines
    forcing new funding decisions to be directly tied to short-term clinical relevance; relevance which can’t be shown in the very early stages of critical research; short-term return expectations, as Mr. Will indicates, required in the private sector which prove to hobble long-term investment advantage in the public sector.

    The historical NIH analogy is actually very relevant; public investment in academic approaches, the realm of trial, error, and peer-reviewed defense not only leading to incredibly accelerated
    private sector financial return but preventative care and health maintenance regimens saving lives and dollars long-term. Again, the same approach Democrats support in the Affordable Health Care Act, energy / alternative fuel / green energy development policy, and a host of
    other federal, state, and local policy initiatives. Short-term private return is not the preferred bell-weather: but rather long-term sustainability.

    But wait, what’s really going on here? Is George Will finally coming around or is he simply taking advantage of the consequences of circumstance to shift blame? Wasn’t it just a few months
    ago that Mr. Will was writing about the ‘President’s Flawed Math about the Sequester’? Wasn’t it the Republicans who were saying, “bring on the sequester, all these dire warnings are nothing but political grandstanding by the Democrats.” Ridiculous!