The Hattiesburg American reports the agency was following up on a complaint filed earlier by the Humane Society of the United States. The complaint alleged welfare and safety violations at the roadside zoo.
The newspaper reports at least 10 trucks from the state agency were at the scene, and officials carried several animal crates, cages and equipment into the zoo.
The zoo sits near U.S. Highway 49 in south Mississippi's Covington County. Gus and Betty White opened the Collins Zoo in 1988.