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Denver Broncos quarterback Peyton Manning motions to teammates during the first half of an NFL football game against the San Diego Chargers, Monday, Oct. 15, 2012, in San Diego. (AP Photo/Lenny Ignelzi )
Manning was 13 of 14 for 167 yards in the second half for the Broncos (3-3) who tied the Chargers atop the AFC West.
Rivers was intercepted four times — three in the fourth quarter — and lost two fumbles.
Manning's 21-yard touchdown pass to Brandon Stokley gave Denver its first lead of the game, 28-24 with 9:03 left. Stokley outleaped defensive back Marcus Gilchrist to catch the ball, and then got both feet down before tumbling out of the end zone.
Harris sealed the victory with a 46-yard interception return for a touchdown with 2:05 left. It was his second pick of the night.
Manning finished 24 of 30 for 309 yards with one interception.