The 61-year-old from Tupelo has held the Senate seat since December 2007.
Wicker’s Democratic challenger this year was 82-year-old Albert N. Gore Jr. of Starkville, a retired United Methodist minister and retired chaplain for the U.S. Army Special Forces.
Also running were the Constitution Party’s Thomas Cramer of Vancleave and the Reform Party’s Shawn O’Hara of Hattiesburg.
Then-Gov. Haley Barbour appointed Wicker to the Senate after fellow Republican Trent Lott resigned. Wicker defeated Democratic former Gov. Ronnie Musgrove in a November 2008 special election to fill the final four years of the term Lott started.
Mississippi’s senior U.S. senator, Republican Thad Cochran, did not have to run this year.