Her death was announced Thursday by Lt. Gov. Tate Reeves. She died at a Jackson hospital after a lengthy illness, friends said. Other details of her death were not been released. Funeral arrangements are pending. She is survived by her husband, Dennis, and a daughter.
"She was a great person, a great legislator and a good community leader, and a good friend," said Rep. Credell Calhoun, D-Jackson.
Harden had served in the Senate since 1988 from Hinds County. She had served as chairman of both the education, universities and colleges and elections committees.
She was re-elected in 2011 and was serving on the appropriations and education committees. Her death opens a second vacancy in the 52-member state Senate. Bennie Turner, a West Point Democrat, died Nov. 27.
Harden was a former teacher and former president of the Mississippi Association of Educators. She was native of Pike County. She got her bachelor's and masters' degrees in education from Jackson State University. She taught physical education and science before being elected to the Senate.
She was education chairman during some lean fiscal years in Mississippi.
In a 2000 interview with the Associated Press, Harden said the challenge of budgetary shortfalls was getting state agencies together to determine what education dollars are already out there.
"We are going to have to do things that don't impact the appropriations process," she said. "That means maximizing the funds throughout state government that impact education. But it takes some collaboration among state agencies. There are policies that we can implement and we can even put off the funding for many of them."
Former Lt. Gov. Amy Tuck, who appointed Harden as education chairwoman in 2000, said in a statement that Harden "always looked out for the best interest of her constituents. Being a former teacher, Senator Harden had a special interest in education issues that affected the children of our state."
Reeves said in a statement that Harden's passion was "for improving Mississippi's schools and universities."
"She fought diligently for all Mississippi children to have an opportunity to receive a good education. Her dedication to public service will be missed," Reeves said.
Gov. Phil Bryant described Harden as "a pioneer for civil rights and a staunch supporter of public education. She served her constituents well and will certainly be missed."
"I had the pleasure to work with her during my term as lieutenant governor and was always impressed with her determination to stand for her beliefs," Bryant said in a statement.
Hinds County Circuit Judge Tomie Green, who served in the Mississippi House and was a long-time friend of Harden, told The Clarion-Ledger that Harden was "a great Christian woman, who gave voice to those who had no voice. Alice was unique. She will be missed by me and she will be missed by the state."
Rep. Cecil Brown, D-Jackson, a longtime friend of Harden's, said: "Alice was a strong voice, not only a supporter of education, but a vocal, hard-working supporter and was adamant about trying to improve education in Mississippi. It's a loss for the Senate, a loss for the state and a loss for Hinds County and Jackson. It will be hard to replace somebody with that many years of experience and that kind of passion."
Kevin Gilbert, president of the Mississippi Association of Educators, said "the MAE family is very saddened" by Harden's death.
"She was a dedicated civil servant and a true champion for children and public education," Gilbert said.
Gilbert said Harden was "a principal leader in gaining increased pay and respectability for the education profession and fought tireless to make sure public education was fair, equitable, and of quality for all students."