A 2000 Isuzu Rodeo was traveling west on Highway 78 in Itawamba County, near the scales just east of Fulton, when it flipped, ejecting three passengers and partially ejecting the driver, said Trooper Ray Hall of the Mississippi Highway Patrol.
Two were taken by ambulance to the North Mississippi Medical Center, and two were airlifted. One was taken straight to The MED in Memphis, while another was taken first to NMMC and then on to Memphis.
Hall said everyone involved in the accident was from out of state.
The Highway Patrol is investigating whether alcohol was involved. No names have been released yet.