Jeremy Rosamond, 27, of Ackerman, and Royce Dan Thompson, Jr., 24, of Randolph, were killed in the accident, said Lee County Coroner Carolyn Green.
Both were pronounced dead on the scene due to multiple trauma. According to the Mississippi Highway Patrol it appears Rosamond was wearing a seatbelt. Thompson was not wearing a seatbelt.
Green said it's unclear if alcohol was involved, but tests have been done and results should be back in 10 days.
A third person was injured in the crash and was transported to North Mississippi Medical Center with serious injuries, according to the MHP.
The crash remains under investigation.
From early Sunday morning:
Lee County, Tupelo and Mississippi Highway Patrol units responded early Sunday to a two-car crash on Highway 6 (West Main Street) at McPherson St., just outside the city limits of Tupelo. The crash happened around 12:30 a.m. Sunday.
Lee County Coroner Carolyn Green confirmed two people were killed in the crash and one person was transported to the hospital.
Police had to shut the roadway down completely, and at 2 a.m. they were still working the scene of the crash.
Police said there was heavy damage to both vehicles.
More as it becomes available.