Arkansas State (11-8) is coming off a Sun Belt Conference sweep of Arkansas-Little Rock. The Red Wolves are coached by former Mississippi State player and assistant Tommy Raffo.
Baldwyn native Tanner Gaines, a 6-foot-1 junior right-hander, who pitched at Northeast Community College last year and Mississippi State the year before that, will start for Arkansas State.
It will be the second start for Gaines, who is 2-0 with a 4.50 earned run average in 14 innings.
Ole Miss will start senior left-hander Jeremy Massie (1-1, 2.20)
The Rebels (17-4) have their first SEC home series this weekend against Missouri.