Miami (5-2) nearly wasted a 30-point halftime lead as the Rebels outscored the Hurricanes 26-6 during a late second-half run. Chris Warren hit consecutive 3-pointers, reducing the Miami lead to 79-70 with 4:10 remaining.
Scott converted four three throws in the next 1:25 to secure the Hurricanes' victory. The game was the first between Miami and Mississippi since a two-game set won by the Hurricanes in 1949.
Reggie Johnson and Adrian Thomas each scored 17 points for Miami. Johnson also grabbed 10 rebounds.
Warren paced the Rebels (3-2) with 23 points, 18 in the second half.
Miami led 57-27 at halftime and increased its advantage to 69-38 on Thomas' 3-pointer with 15:11 remaining in the second half.
The Hurricanes shot 61 percent on 23-of-38 shooting from the field in the first half and 7 of 13 behind the arc.
Scott's jumper with 56 seconds left in the first half gave the Hurricanes their first 30-point lead, 55-25.
Thomas hit two 3-pointers as Miami built a 20-6 lead in the first 7:26. Johnson's putback basket with 12:34 remaining in the half capped the run.
The Hurricanes ran off nine unanswered points later in the half and increased their lead to 32-11 on Scott's basket with 8:45 left.
Miami kept Warren scoreless until his 3-pointer with 3:29 remaining in the first half.
Warren, the Rebels' leading scorer, entered the game with a 16.8 points-per-game average.