Tipoff at the new Auburn Arena is 6 p.m.
The Rebels knocked off Vanderbilt in their SEC opener but dropped an 86-46 road game at No. 5 Tennessee last Sunday.
Freshman point guard Valencia McFarland, recovering from a December injury, led Ole Miss with 16 points at Tennessee. The Rebels are 0-4 in true road games this season.
Led by guards Alli Smalley (12.3 ppg) and Blanche Alverson (11.1 ppg), the Tigers last week won 73-56 against Florida but lost 67-59 at Vanderbilt.
Ole Miss and Auburn have split the last 10 meetings.