People would pay an additional $50 for the Saints tag in Mississippi.
The plate will have the same design as one in Louisiana, with a black-and-gold fleur-de-lis and the Super Bowl XLIV logo.
Most of the fee will be distributed to Infinity Science Center, a tourist attraction being built at NASA's Stennis Space Center in coastal Hancock County.
Infinity is a $40 million, 72,000-square-foot museum created in partnership with Stennis Space Center on 200 acres adjacent to the welcome center at Exit 2 on Interstate 10.
The bill is House Bill 705.