Those names topped the list of babies born in the state last year, according to Social Security card applications.
Gone are Mary and Lisa, which hit the top in the 1960s, and even Jennifer and Ashley, which were most popular in the 1980s.
Those four didn't even crack Mississippi's top 100 names in 2010.
Instead, we're seeing a lot more of the less-traditional Chloe and Makayla, both of which barely registered a blip in the 1980s.
"Culture really influences the popularity of female names," said Melissa Lea, a psychology professor at Millsaps College.
According to recent Social Security Administration statistics, the Top 5 names given to girls born in Mississippi in 2010 were — in order of most popular — Madison, Emma, Addison, Isabella and Ava. For boys, William, James, Jayden, John and Elijah topped the list.
Lea has studied name trends dating to the 1950s and the perception of names.
What she's found: Girl names tend to be trendy and transition every few years, while the male names tend to be more traditional — particularly biblical or family names.
Names like William, James, Christopher and Michael always seem to make the top 10.
Jackson resident Camillia Castill named her 20-year-old son, James, after her husband.
"Another reason I also picked it is because I know it is one of the names in the Bible," she said.
With names like Joseph, Christian and Noah making the top 25, others appear to be following those cues as well.
There can be a downside to having the more tried-and-true names, though.
For instance, Castill said of her son, "A lot of his teachers have gotten him confused with other students name James."
Meanwhile, female names tend to reflect more pop culture influences.
Ava has grown in popularity since 1999, when actress Reese Witherspoon named her daughter that.
Emma was the name Jennifer Aniston's character bestowed on her daughter in the television show Friends.
And Isabella - the name of the Twilight protagonist — has shot up in popularity alongside the book and movie series.
Even those with less than stellar reputations can spark a wave of names, Lea said.
"We've seen that with a lot of Lindsays coming up," she said, noting much of that is likely because of the popularity of actress Lindsay Lohan.
As for guys: "I doubt we will start seeing a lot of Charlies," she said, noting actor Charlie Sheen's well-publicized, erratic behavior.
Copyright 2011 The Associated Press.