The first fire was on Lee County Road 1001 near Plantersville at about 8 a.m. No one was injured but the home was a total loss.
Union, Mooreville/Eggville, Richmond and Plantersville departments responded to the blaze.
Hours later, at about 11:55 a.m., a call came in to 911 about a fully-involved house fire at 1049 Highway 145 between Guntown and Baldwyn.
Guntown, Baldwyn, Saltillo, Cedar Hill and Unity-Fellowship fire departments were still battling the blaze about an hour later.
The family inside ran to safety and were OK. The house was also a total loss.
Both fires are under investigation to determine the causes.