The Bulldogs (6-5, 4-1) took a 51-0 lead into the locker room at halftime.
"We executed, got the ball downfield and Channing came in and sparked us at the start at tailback," Aberdeen coach Chris Duncan said.
South Pontotoc ends its season at 3-8, 1-4.
Atlanta Falcons tight end and Aberdeen native Reggie Kelly talked with Aberdeen and led the team in a pregame prayer.
Last week, Aberdeen lost 20-14 at Water Valley, its first division loss in three years. Next week, the Bulldogs, the division's No. 2 seed, will host the No. 3 seed from Division 4-3A.
"We needed the confidence and to get back to playing well," Duncan said. "We played hard and with a little enthusiasm and I think they were fired up to be playing. I think last week kind of woke us up a little bit."
Aaron McMillian Jeremy Brandon has touchdown catches from freshman quarterback Josh Williams and Josh Ewing ran back a free kick after a first-half safety caused by Jordan Gathings.