The game was tied 49-49 with 8 minutes to play before the Blazers (10-13, 5-5 Conference USA) scored seven consecutive points to take the lead for good. Southern Miss (20-4, 7-2) never pulled closer than four points the rest of the way.
UAB's Jordan Swing scored five of his 15 points in the final 4 minutes, including a 3-pointer that gave the Blazers a 65-57 lead.
Jonathan Mills led the Golden Eagles with 14 points. Mills, one of the Golden Eagles' best interior players, scored only two points in the first half after picking up two fouls in the first 3 minutes.
The Blazers made eight of their first nine shots to take an 18-14 lead, and led 32-28 at halftime.