MSU (23-19, 6-14 SEC) trailed 3-1 with two outs in the last inning before mounting a rally. All five of the Bulldogs’ runs came with outs.
Sharpe, who had a pair of hits, tied a career-high with four RBI.
Pitcher Kylie Vry (8-6) retired 10 consecutive batters in relief for MSU with five strikeouts.
Kendall Bruning (12-12) took the loss for Ole Miss (16-22, 3-12).
The second game of the series is today at 2 p.m.