The Justice Department says Holder's speech is titled, "50 Years of Integration —1962-2012: A Reflection on Civil Rights in America."
It's one of several events Ole Miss is sponsoring to commemorate James Meredith's court-ordered enrollment as the university's first black student on Oct. 1, 1962.
Holder's speech begins at 7 p.m. Thursday at the Gertrude C. Ford Center for the Performing Arts on the Oxford campus. It is free, but tickets are required for admission.
Two people were killed and more than 100 were injured as integration opponents converged on Oxford in 1962. U.S. marshals escorted Meredith while he registered and attended classes. He graduated in August 1963 with a degree in political science.