Guntown Fire Chief David Wood reported three people were injured in a house fire on Ford Avenue Monday night.
One of the family members was taken to the burn center in Brandon and two more were transferred to a burn center in Augusta, Ga. from the North MIssissippi Medical Center.
Wood said the fire started around 10:30 p.m. and they had it out around midnight.
Wood said he would call the house a total loss and at this point in time cannot determine what started the fire.
At least three family members, two of them children, suffered burns in a mobile home fire on Monday night in Guntown.
The first call for the fire, on the 600 block of Ford Ave., went out at about 10:40 p.m. Members of the Guntown, Saltillo and Baldwyn fire and police departments converged on the scene.
A police officer said there may have been five children in the home and that all family members had gotten out.
Two children were transported to North Mississippi Medical Center by air ambulance. One of the children was reported to be severely burned.
A 40-year-old was transported to NMMC by ground ambulance. A fourth person may have been injured in the fire.
The air ambulance landed at the hospital in Tupelo about 50 minutes after the first fire call.
The flames were out shortly after 11:30 p.m. as firefighters entered what remained of the home and tried to gather clues about what started the blaze.
The home appeared to be a total loss. Another home within feet of the fire was untouched.
Brandon Speck and John L. Pitts contributed to this story.