Jeremy Keith Huguley and Charles David Burleson II face up to life in prison or the death penalty if convicted.
They were indicted in October 2010, accused of killing Holley while allegedly taking his cash, a wallet, a 42-inch flat screen TV, a DVD player, a cell phone and an electric cordless drill.
Capital murder is a murder committed along with another felony.
Their indictment claims Holley was struck in the head with a pipe or piece of metal on May 15, 2010.
Jury selection began Monday in the Prentiss County Courthouse, where another murder trial was halted last Wednesday after the defendant failed to appear because she was hospitalized.
Judge James L. Roberts Jr. presides over the new trial.
Prosecutors include District Attorney Trent Kelly and Assistant D.A. John Weddle.
Tupelo attorney John Helmert represents Huguley and Burleson.