The object of the alleged conspiracy, a three-count federal indictment states, was to establish a cocaine and marijuana distribution network to continuously supply customers.
Wednesday, two of the defendants were brought for an initial appearance before Magistrate S. Allan Alexander, who ordered their detention.
All 10 are accused of the conspiracy in Count One. Their alleged illegal acts occurred from Oct. 1, 2011, through May 31, 2012 in Tupelo and Okolona.
They are Denorris Howell, 29, of Waterford, Eric Mills, 36, of Rienzi, Shawn Michael Brown, 38, and Marty Lambert, 43, both of Booneville, Brandon Demario Wells, 23, of Decatur, Ill., and all from Corinth, Jay Hill, 29, Qavis Deron Green, 25, Antonio Bean, 35, Kenneth Scales, 48, and Arielle Wells, 23.
Count Two accuses Mills of possessing firearms in the alleged commission of drug trafficking.
Mills is the only one accused of possession of a firearm by a convicted felon in Count Three.
If convicted, they all are subject to forfeiture of anything they derived from the illegal activities.
Punishments range from five years in prison and $250,000 fine to 30 years in prison and $2 million fines, the more severe for anyone with a prior drug felony conviction.
Alexander ordered Hill and Mills temporarily detained.
No others have made any court appearances yet.