Reginald Buckner scored 11 points while Nick Williams and Murphy Holloway added 10 points apiece for Ole Miss (7-1). Henderson hit six 3-point shots and was 7 of 15 from the field. The Rebels shot 43.8 percent (28 of 64) from the field.
Lester Wilson led East Tennessee State (2-6) with 14 points. Jarvis Jones and Mario Stramaglia added 11 points apiece. The Buccaneers shot 32.7 percent (18 of 55) from the field.
East Tennessee State led 16-13 after the opening 10 minutes, but Ole Miss rallied to take a 33-22 halftime lead. The Buccaneers never closed within nine points in the second half.