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Timothy Spraggins, 20, is accused on four counts of distributing cocaine in March and July 2011.
Avis Robinson, 30, is accused on six counts of distributing cocaine in October and November 2011.
The two are accused of illegal acts in Clay, Chickasaw and Monroe counties.
Both had initial appearances Friday before Magistrate David Sanders and were ordered temporarily detained until their arraignments and detention hearings set for Dec. 19.