Dozens of defendants have been indicted during the past year on similar accusations.
This time, three sets of arrests center on claims of drug activity in Lowndes County.
In this latest round, nine people were indicted in late January, but the charges against them were not made public until recently.
Four men and a woman face a March 18 trial on accusations they conspired to possess and sell cocaine.
They are Marcus “Lil Mark” Cockrell, 32, Thomas “Conehead” Cattladge, 42, and Porsha Mixon, 28, all of Columbus, and Steven Cathey, 34, of Olive Branch, and Nicholas Antonio Langston, 28, of Coldwater.
Cockrell continues to be held on three counts, including possession of a firearm by a convicted felon. The others were released on secured bonds.
The indictment claims their conspiracy and other illegal acts occurred from about August 2011 through August 2012.
Four Columbus residents face drug charges in a second case.
They are Lafredrick Deandre Jackson, 29, Devorris Hill, 28, Latoria Bridges, 26, and Marcus Walker, 34.
The indictment claims their conspiracy occurred from about August 2011 through August 2012.
Jackson also is accused of possession of a firearm by a convicted felon. He waived appearance at his arraignment Thursday.
He and Jackson remain in jail while Bridges and Hill are free on bond.
In the third case, Anthony Hill, 34, of Artesia, is free on bond after indictment on two counts that he possessed cocaine with the intent to distribute it.
He faces a March 18 trial date.
His indictment claims he committed illegal acts in September 2011.
A fourth indictment accuses Jamel Banks, 33, of West Point of 10 counts of selling cocaine in Monroe and Clay counties.
He was indicted last October for a illegal acts alleged during 2011. His trial also is set for March 18.