She held a news conference Monday in Oxford to announce that she's seeking the Republican nomination.
The GOP is hoping to unseat Democrat Travis Childers, who has held the 1st District seat since mid-2008.
McGlowan faces state Sen. Alan Nunnelee of Tupelo and former Eupora Mayor Henry Ross in the June 1 Republican primary.
She is a Lafayette County native and has worked as a Fox News analyst. She published a book in 2007 called, "Bamboozled: How Americans Are Being Exploited by the Lies of the Liberal Agenda."
McGlowan spoke this past weekend at a national Tea Party convention in Nashville.