According to Mississippi Highway Patrolman Ray Hall, the wreck happened about 10:45 p.m. when a motorcyclist lost control.
Kenneth Todd, 44, of Myrtle was traveling west on Hwy. 78 on a 1987 Honda motorcycle when he apparently lost control of his vehicle and collided into a bridge rail. Hall said Todd was ejected from the motorcycle and thrown into westbound traffic.
He was struck by a 1992 Buick driven by Leigh Ann Perris, 46, of Myrtle and was pronounced dead at the scene.
The accident is under investigation.