McDonald, who will be a senior this fall at Itawamba AHS, will play in the girls tournament scheduled for July 19-24 at the Country Club of North Carolina in Pinehurst, N.C. She recently committed to play for Mississippi State.
Ramey, the state's Class 4A medalist for the state champion IAHS team this spring, will play in the boys tournament scheduled for the same dates at Egypt Valley Golf Club in Ada, Mich. Ramey will be a freshman this fall at MSU.
"They're both playing really well," said Michael Nanney, the IAHS golf coach. "Both of them work really hard. I'm not surprised they qualified."
McDonald, who qualified for the tournament last year, earned her second straight berth this summer in a USGA qualifier tournament at Old Waverly.
Ramey earned his first berth in the national event with his play last month in a qualifier event at the Old Fort Golf Club in Murfreesboro, Tenn.
The format for both national tournaments is two days of qualifying stroke play, followed by two rounds of match play. McDonald missed qualifying for the final two rounds last year by one stroke.
McDonald is playing this week at the American Junior Golf Association's Rolex Tournament of Champions in Springdale, Ark.