Marshall Henderson, who made 5 of 10 from 3-point range, added 17 points for the Rebels (3-0). Nick Williams scored 12 points, Murphy Holloway had 11 and Reginald Buckner added 10 and a team-high 11 rebounds in the balanced attack.
John Gillon scored 14 points for Arkansas-Little Rock (1-2), which shot just 29.7 percent from the field (19 of 64). The Trojans led 10-3 in the opening four minutes but trailed by as many as 42 points, 81-39, in the second half.
Ole Miss, which led 47-33 at halftime, shot 52.4 percent (33 of 63) from the field and forced 20 turnovers. The Rebels held a decisive 47-34 edge in rebounds and blocked eight shots.