The teenager made an initial court appearance Friday. He remains in the Lowndes County jail.
The shooting occurred just minutes after midnight at the Crossroads lounge on Mississippi Highway 182 at the Lowndes-Oktibbeha County line. Authorities say the incident occurred during a Valentine's Day party. Other details were not released.
Oktibbeha County Coroner Michael Hunt says 23-year-old Trumaine Q. Macon of Starkville was shot and was pronounced dead at OCH Regional Medical Center.
Lowndes County Chief Deputy Marc Miley says the shooting investigation is continuing.