ICC, which won a school record 30 games a year ago, will open its campaign against perennial power, Gulf Coast, on Feb. 9 in Fulton.
"We have beefed up our schedule even more to get us ready for the post-season," said Case. "We were happy to have made the post-season the last two years but we've got to have more success when we get there."
It was the first time in the history of the program that the Lady Indians qualified for back-to-back appearances in the playoffs.
"I like our team and we are going to work hard again in January to get ready for our season," added Case, who was an assistant baseball coach at the College the previous five seasons before taking over the softball program.
Itawamba will open division play on March 10 at Mississippi Delta.