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Ashley Scott, 25, of Baldwyn, died in the crash that happened around 8:20 p.m. on Highway 45 Wednesday. Lee County Coroner Carolyn Green said she wasn't wearing a seat belt at the time of the crash.
Scott children riding in the car with her were taken to the North Mississippi Medical Center for treatment.
Scoot was traveling west on County Road 2878 when Green said it appears she pulled out in front of a car traveling southbound on Highway 45.
Green said she has not received an update on the three children.