The vehicle in which Robert Bruce Smith IV, 69, died had rolled over during the accident.
According to Saltillo Police Chief Grant Bailey, two vehicles were traveling south on 45 South near Pro Turf around 11:30-11:45 p.m.
Smith was dead on arrival at North Mississippi Medical Center. The driver of the other vehicle, a 39-year-old man from Saltillo, was transported to NMMC with serious injuries.
Saltillo police have asked the Mississippi Highway Patrol to assist with the accident reconstruction.